Last Updated on: 4th September 2024, 05:12 pm
Summary
| Diagnosis | Sex | Age | Nationality |
|---|---|---|---|
| Optic Nerve Hypoplasia (ONH) / Septooptic Dysplasia (SOD) | Female | 10 years | Brazilian |
| Injections | Cell type | Admission date | Discharge date |
| 8 | UCBSC | March 11th 2019 | March 28th 2019 |
Condition On Admission
The patient had light perception only. She had hormone deficiency (GH, thyroid, and cortisol) due to an atrophy in the pituitary gland.
Treatment Schedule
The patient received 8 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV), intrathecal and retrobulbar injections, as per the schedule below:
| Number | Date | Cell Type | Delivery Method | Side Effects |
|---|---|---|---|---|
| 1 | 2019-03-12 | UCBSC | Intravenous Injection | none reported |
| 2 | 2019-03-15 | UCBSC | Intrathecal Injection & Intravenous Injection |
none reported |
| 3 | 2019-03-18 | UCBSC | Retrobulbar Injection & Intrathecal Injection |
none reported |
| 4 | 2019-03-22 | UCBSC | Retrobulbar Injection & Intrathecal Injection |
none reported |
| 5 | 2019-03-26 | UCBSC | Intravenous Injection | none reported |
Condition at discharge
At discharge the patient already started to show some improvements; She could move her eyes following directions better than before. She could slowly move her eyes up and down and left and right. She could name the colors yellow, red, blue and purple by looking at colored lights (after she learned these colors). In addition, she could compare the size of shiny objects, finding out which ones were smaller or bigger and she could also identify their shapes.Condition 12 months after treatment
At the 12 month follow up point, the patient’s parents reported that the patient’s quality of life had moderately improved and that improvements were continually being made. They also mentioned: “Before the treatment he only had light perception, today he is able to count on fingers.” Please see an excerpt from the patient’s parents 12 month assessment below:
| Symptom | Parents’ Assessment of Improvement |
| Ability to focus eyes quickly | Small improvement |
| Ability to keep eyes focused for a long time | Moderate improvement |
| Ability to see hand movement | Moderate improvement |
| Ability to see things at a close distance | Moderate improvement |
| Ability to see things at a far distance | Significant improvement |
| Ability to see things clearly | Small improvement |
| Able to count fingers | Moderate improvement |
| Blindness | Moderate improvement |
| Colour vision | Significant improvement |
| Light perception | Moderate improvement |
| Night vision | Significant improvement |
| Nystagmus | Moderate improvement |
| Strabismus | Small improvement |
| Vision in left eye | Moderate improvement |
| Vision in right eye | Moderate improvement |
| Visual field | Small improvement |