Last Updated on: 4th September 2024, 05:12 pm
Summary
| Diagnosis | Sex | Age | Nationality |
|---|---|---|---|
| Optic Nerve Hypoplasia (ONH) / Septooptic Dysplasia (SOD) | Female | 2 years | USA |
| Injections | Cell type | Admission date | Discharge date |
| 7 | UCBSC | June 21st 2011 | July 11th 2011 |
Condition On Admission
The patient was admitted for treatment for her vision problem. Physical examination showed the movement of her eyeballs was good. Spontaneous nystagmus was present. Her pupils were normal in shape and reactive to light. The patient could differentiate between light and dark. Eye tests could not be conducted due to her young age; therefore it was difficult to confirm her exact visual acuity. The other tests after admission showed no significant abnormalities.
Treatment Schedule
The patient received 7 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV) injections as per schedule below:
| Number | Date | Cell Type | Delivery Method | Side Effects |
|---|---|---|---|---|
| 1 | 2011-06-24 | UCBSC | Intravenous Injection | none reported |
| 2 | 2011-06-27 | UCBSC | Intravenous Injection & Intravenous Injection |
none reported |
| 3 | 2011-07-01 | UCBSC | Intravenous Injection & Intravenous Injection |
none reported |
| 4 | 2011-07-04 | UCBSC | Intravenous Injection & Intravenous Injection |
none reported |
Condition at discharge
After treatment the doctors noted the patient could track light with her right eye and the frequency of nystagmus had reduced. The family were pleased with the improvements their daughter had gained during the treatment, especially the improvements in her vision. They also reported at the time of discharge that her bowel function had also improved. The patient was now having a daily bowel movement, whereas prior to treatment it was every 2 or 3 days.
| Symptom | Parents’ Assessment of Improvement |
| Light perception | Moderate improvement |
| Vision in left eye | Small improvement |
| Vision in right eye | Moderate improvement |
| Ability to see things clearly | Small improvement |
| Ability to focus eyes quickly | Small improvement |
| Ability to keep eyes focused for a long time | Moderate improvement |
| Ability to see things at a far distance | Small improvement |
| Nystagmus (uncontrolled eye movement) | Small improvement |
Condition 3 months after treatment
The parents completed the Beike follow-up survey three months after the treatment. They were pleased with the improvements the treatment had given their daughter for both her physical condition and quality of life. In addition to the improvements in the symptoms listed below, the parents felt their daughter had more confidence to move around. Below is an excerpt from the parent’s completed 3-month follow-up survey:
| Symptom | Parents’ Assessment of Improvement |
| Blindness | Moderate improvement |
| Light perception | Moderate improvement |
| Ability to see hand movement | Significant improvement |
| Able to count fingers | Significant improvement |
| Vision in left eye | Significant improvement |
| Vision in right eye | Small improvement |
| Color Vision | Small improvement |
| Night vision | Small improvement |
| Ability to see things clearly | Significant improvement |
| Ability to focus eyes quickly | Significant improvement |
| Ability to keep eyes focused for a long time | Significant improvement |
| Ability to see things at a close distance | Moderate improvement |
| Ability to see things at a far distance | Significant improvement |
| Nystagmus (uncontrolled eye movement) | Significant improvement |
Condition 12 months after treatment
The parents also completed a Beike follow-up survey one year after their daughter’s treatment. They were satisfied with the outcome of the treatment and felt their daughter had made significant improvements in her quality of life and had further improved in her overall physical condition. Below is an excerpt from the parent’s completed 1 year follow-up survey:
| Symptom | Parents’ Assessment of Improvement |
| Blindness | Significant improvement |
| Light perception | Moderate improvement |
| Ability to see hand movement | Moderate improvement |
| Able to count fingers | Significant improvement |
| Vision in left eye | Significant improvement |
| Vision in right eye | Small improvement |
| Visual field | Small improvement |
| Color Vision | Significant improvement |
| Night vision | Small improvement |
| Ability to see things clearly | Moderate improvement |
| Ability to focus eyes quickly | Small improvement |
| Ability to keep eyes focused for a long time | Moderate improvement |
| Ability to see things at a close distance | Moderate improvement |
| Ability to see things at a far distance | Small improvement |
| Nystagmus (uncontrolled eye movement) | Significant improvement |