Ataxia
Autism
Autoimmune Disorders
Cancer
Cerebral Palsy
Covid 19
Crohn’s Disease
Diabetes
Duchenne muscular dystrophy (DMD)
Lupus
Muscular Dystrophy
Optic Nerve Atrophy
Parkinsons
Spina Bifida
Spinal Cord Injury
Spinal muscular atrophy
Spinal Muscular Atrophy (SMA)
Stem Cell Medical Reports for:

Allogeneic Mesenchymal Stem Cell Therapy with Laromestrocel in Alzheimer’s Disease: A Phase 2a Trial

Author or authors of report : Brian G. Rash, Kevin N. Ramdas, Anthony A. Oliva Jr.
Date of report : 2025-03-10
Alzheimer's Disease
Nature Medicine
Summary of the Main Points/Findings Background and Objective: This randomized, double-blind, placebo-controlled, parallel-group phase 2a clinical trial aimed to assess the safety and efficacy of laromestrocel, a bone-marrow-derived allogeneic mesenchymal
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Pre-clinical Safety and Efficacy of Human Induced Pluripotent Stem Cell-Derived Midbrain Dopaminergic Progenitor Cells for Parkinson’s Disease

Author or authors of report : Jeha Jeon, Young Cha, Yean Ju Hong, In-Hee Lee, Heejin Jang, Sanghyeok Ko, Serhiy Naumenko, Minseon Kim, Hannah L. Ryu, Zenith Shrestha, Nayeon Lee, Tae-Yoon Park, HoeWon Park, Seo-Hyun Kim
Date of report : 2025-03-06
Parkinsons
Cell Stem Cell
Summary of the Main Points/Findings: Background and Objective: This preclinical study aimed to assess the safety, quality, and functional potential of midbrain dopaminergic progenitor cells derived from patient-specific human induced
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Industry Updates from the Field of Stem Cell Research and Regenerative Medicine November 2024 (Summary)

Author or authors of report : Dusko Ilic and Mirjana Liovic
Date of report : 2025-01-19
Autoimmune Disorder, Cancer, Degenerative Disease
Regenerative Medicine Journal (Taylor & Francis Group)
Summary of the Main Points/Findings Background and Objective: This report offers a curated overview of major commercial and scientific developments within the field of stem cell research and regenerative medicine
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Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A

Author or authors of report : Alok Srivastava, M.D., Aby Abraham, D.M., Fouzia Aboobacker, D.M., Gurbind Singh, Ph.D., Tulasi Geevar, M.D., Uday Kulkarni, D.M., Sushil Selvarajan, D.M. , Trent Spencer, Ph.D.
Date of report : 2024-12-09
Hemophilia
New England Journal of Medicine
Summary of the Main Points/Findings Background and Objective: This single-center study aimed to evaluate the safety and efficacy of autologous CD34+ hematopoietic stem cells (HSCs) transduced with a lentiviral vector
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Allogeneic Umbilical Cord-Derived Mesenchymal Stromal Cells in Severe Systemic Lupus Erythematosus: A Phase 1 Trial

Author or authors of report : Prof Dominique Farge, MD, Lucie Biard, PhDd, Ben Weil, EngDe, Virginie Girault, PhD, Pauline Lansiaux, PhD, Ingrid Munia, MS, Séverine Loisel, PhD, Catney Charles, BSca, Judikael Saout, PhD
Date of report : 2024-12-17
Lupus (SLE)
Fondation du Rein, ANR eCellFrance
Summary of the Main Points/Findings Background and Objective: This phase 1, dose-escalation trial aimed to assess the safety and preliminary efficacy of allogeneic umbilical cord-derived mesenchymal stromal cells (UC-MSCs) in
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Induced Pluripotent Stem-Cell-Derived Corneal Epithelium for Transplant Surgery

Author or authors of report : Takeshi Soma, MDa, Yoshinori Oie, MDa, Hiroshi Takayanagi, MSa, Shoko Matsubara, BA, Tomomi Yamada, PhDd, Masaki Nomura, PhD
Date of report : 2024-11-16
Corneal Degeneration
The Lancet
Summary of the Main Points/Findings: Background and Objective: This single-arm, open-label, first-in-human interventional study in Japan aimed to assess the safety and feasibility of transplanting induced pluripotent stem-cell-derived corneal epithelium
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Creating Functional Hematopoietic Stem Cells from iPS Cells for Blood Disorders and Beyond (Report summary)

Author or authors of report : Elizabeth S. Ng, Gulcan Sarila, Jacky Y. Li, Hasindu S. Edirisinghe, Ritika Saxena, Shicheng Sun, Freya F. Bruveris, Tanya Labonne, Nerida Sleebs, Alexander Maytum, Raymond Y. Yow, Chantelle Inguanti, Ali Motazedian, Vincenzo Calvanese, Sandra Capellera-G
Date of report : 2024-09-02
Spinal Cord Injury
Nature Biotechnology
Objectives of the Report The report aimed to develop a reliable method to turn human induced pluripotent stem cells (iPS cells) into functional hematopoietic stem cells (HSCs). These cells needed
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Preclinical Evaluation of Transaxial Intramutaminal Trajectory for Enhanced Distribution of Grafted Cells in Parkinson’s Disease Summary

Author or authors of report : Marina E. Emborg, MD, PhD, and colleagues
Date of report : 2024-07-26
Parkinsons
Aspen Neuroscience, Inc.
Introduction This comprehensive study, conducted by Marina E. Emborg and colleagues, published on July 26, 2024, investigates a novel surgical technique for administering human-induced pluripotent stem cell-derived dopaminergic neuroprogenitor cells
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Summary of the Report “MSCs Mediate Long-term Efficacy in a Crohn’s Disease Model by Sustained Anti-inflammatory Macrophage Programming via Efferocytosis

Author or authors of report : Maneesh Dave, Atul Dev, Rodrigo A. Somoza, et al.
Date of report : 2024-01-20
Crohn’s Disease
Research was conducted in partnership with the Australian Regenerative Medicine Institute.
Introduction and Background The study, led by Maneesh Dave and a diverse team of researchers, explores the therapeutic potential of human bone marrow-derived mesenchymal stem cells (hMSCs) in treating Crohn’s
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Stem Cell Treatments Leading the Charge to Cure Cancer

Date of report : 2024-07-05
Cancer
Xianjing Chu, Wentao Tian, Jiaoyang Ning, Gang Xiao, Yunqi Zhou, Ziqi Wang, Zhuofan Zhai, Guilong Tanzhu, Jie Yang & Rongrong Zhou
Cancer stem cells (CSCs), a small subset of cells within tumors, possess self-renewal capabilities and play a crucial role in tumorigenesis, metastasis, and therapeutic resistance. These cells contribute significantly to
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Stem Cells Used to Succesfully treat Type 2 Diabetes

Author or authors of report : Jiaying Wu, Tuo Li, Meng Guo, Junsong Ji, Xiaoxi Meng, Tianlong Fu, Tengfei Nie, Tongkun Wei, Ying Zhou, Weihua Dong, Ming Zhang, Yongquan Shi, Xin Cheng, Hao Yin & Clinical Group
Date of report : 2024-04-30
Diabetes
The report details a study that involved the treatment of a type 2 diabetic (T2D) patient using personalized endoderm stem cell-derived islet tissues (E-islets). The patient, a 59-year-old man with
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Stem cell therapy: A promising treatment for COVID-19 (Summary)

Author or authors of report : Zhi-Xue Zheng
Date of report : 2021-12-16
Covid 19
This report is an invited article and was externally peer-reviewed, with no specific commissioning body mentioned.
Summary of the Main Points/Findings: Background and Objective: The article reviews the potential of mesenchymal stem cell (MSC) therapy as a treatment for COVID-19. COVID-19, caused by SARS-CoV-2, has become
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Safety and efficacy of mesenchymal stem cells in COVID‐19 patients: A systematic review and meta‐analysis (Summary)

Author or authors of report : Cai Yan, Minjie Hu, Rongjuan Dai
Date of report : 2023-08-09
Covid 19
The Fund project of University of South China for Prevention and Control of COVID‐19 The Scientific Research Fund Project of Hunan Provincial Health Commission The Special Fundamental Research Project of COVID‐19 Prevention and Control of Hengyang Science
Summary of the Main Points/Findings: Background and Objective: The study titled "Safety and efficacy of mesenchymal stem cells in COVID‐19 patients: A systematic review and meta-analysis" aimed to evaluate the
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Human mesenchymal stem cell therapy in severe COVID-19 patients Report

Author or authors of report : Tian-Tian Li, Bo Zhang, Hui Fang, Ming Shi, Wei-Qi Yao, Yuanyuan Li, Chao Zhang, Jinwen Song, Lei Huang, Zhe Xu, Xin Yuan, Jun-Liang Fu, Cheng Zhen, Yu Zhang, Ze-Rui Wang, Zi-Ying Zhang, Meng-Qi Yuan, Tengyun Dong, Ruidan Bai, Lulu Zhao, Jianming Cai, Jin
Date of report : 2023-05-10
Covid 19
The National Key Research and Development Program of China, The Innovation Platform for Academicians of Hainan Province, and the Fund of National Clinical Center for Infectious Diseases, PLA General Hospital.
Summary of the Main Points/Findings: Background and Objective: The study aimed to evaluate the long-term safety and efficacy of human mesenchymal stem cell (MSC) treatment in severe COVID-19 patients over
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Stem cell therapy for muscular dystrophies Report Summary

Author or authors of report : Stefano Biressi, Antonio Filareto, Thomas A. Rando
Date of report : 2020-10-12
Muscular Dystrophy
Abstract: Muscular dystrophies are a diverse group of genetic diseases marked by progressive degeneration of skeletal and cardiac muscle. Despite extensive research into various therapeutic options, no definitive treatment has
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A clinical study shows safety and efficacy of autologous bone marrow mononuclear cell therapy to improve quality of life in muscular dystrophy patients Report Summary

Author or authors of report : Alok Sharma, Hemangi Sane, Prerna Badhe, Nandini Gokulchandran, Pooja Kulkarni, Mamta Lohiya, Hema Biju, V C Jacob
Date of report : 2013-09-10
Muscular Dystrophy
  Major Points: No Adverse Events: The study reported no significant adverse events, indicating the safety of the treatment. Neurological Improvements: Post-transplantation assessments showed improvements in trunk muscle strength, limb
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Efficacy of stem cell therapy in ambulatory and nonambulatory children with Duchenne muscular dystrophy Report Summary

Author or authors of report : Alper Dai, Osman Baspinar, Ahmet Yeşilyurt, Eda Sun, Çiğdem İnci Aydemir, Olga Nehir Öztel, Davut Unsal Capkan, Ferda Pinarli, Abdullah Agar, Erdal Karaöz
Date of report : 2018-10-26
Muscular Dystrophy
  Major Points and Findings: Purpose: The study aimed to investigate the effects of allogeneic Wharton jelly-derived mesenchymal stem cells (WJ-MSCs) therapy in children with Duchenne muscular dystrophy (DMD). DMD
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Autologous bone marrow mononuclear cell transplantation in Duchenne muscular dystrophy Report Summary

Author or authors of report : Alok Sharma, Hemangi Sane, Amruta Paranjape, Khushboo Bhagawanani, Nandini Gokulchandran, Prerna Badhe
Date of report : 2014-03-28
Duchenne muscular dystrophy (DMD)
Major Points and Findings: Background: DMD is a progressive degeneration of striated muscles, leading to loss of function and premature death. Current treatments are palliative and do not alter the
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Duchenne muscular dystrophy Report Summary

Author or authors of report : Dorota Sienkiewicz, Wojciech Kulak, Bożena Okurowska-Zawada, Grażyna Paszko-Patej, Katarzyna Kawnik
Date of report : 2015-07-08
Muscular Dystrophy
Duchenne Muscular Dystrophy (DMD) Overview: DMD is the most commonly inherited pediatric muscle disorder. It is an X-linked genetic progressive and degenerative myopathy characterized by muscle wasting and weakness. This
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Eteplirsen in the treatment of Duchenne muscular dystrophy Report Summary

Author or authors of report : Kenji Rowel Q Lim, Rika Maruyama, Toshifumi Yokota,
Date of report : 2017-02-28
Muscular Dystrophy
Summary of Medical Report on Eteplirsen for Duchenne Muscular Dystrophy The medical report titled "Eteplirsen in the treatment of Duchenne muscular dystrophy" focuses on the efficacy, safety, and pharmacology of
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Cell Replacement Therapy for Retinal and Optic Nerve Diseases: Cell Sources, Clinical Trials and Challenges Report Summary

Author or authors of report : Rosa M. Coco-Martin, Salvador Pastor-Idoate, Jose Carlos Pastor, Yolanda Diebold, and Laura García-Posadas
Date of report : 2021-06-11
Optic Nerve Atrophy
Major Points and Findings: Objective: The review aimed to provide an update on the potential of cell therapies to restore or replace damaged and/or lost cells in retinal degenerative and
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Gene Therapy for Duchenne Muscular Dystrophy Report Summary

Author or authors of report : Nertiyan Elangkovan, George Dickson
Date of report : 2021-11-30
Muscular Dystrophy
  Introduction to Duchenne Muscular Dystrophy (DMD) DMD is an X-linked muscle-wasting disease affecting 1 in 5000 males. Affected individuals typically become wheelchair-bound by the age of twelve and often
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Stem cell treatment of degenerative Eye Disease Report Summary

Author or authors of report : Ben Mead, Martin Berry, Ann Logan, Robert A.H. Scott, Wendy Leadbeater, Ben A. Scheven
Date of report : 2015-05-14
Optic Nerve Atrophy
Abstract: Stem cell therapies are being researched extensively for treating degenerative eye diseases. These therapies aim to replace lost neurons, restore neural circuits, or provide paracrine-mediated therapies where stem cell-derived
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Diagnosis and management of Duchenne muscular dystrophy Report Summary

Author or authors of report : Prof David J Birnkrant, Prof Katharine Bushby, Carla M Bann, Prof Susan D Apkon, Angela Blackwell, David Brumbaugh, Laura E Case, Prof Paula R Clemens, Stasia Hadjiyannakis, Shree Pandya, Natalie Street, Jean Tomezsko, Prof Kathryn R Wagner, Leanne M Ward
Date of report : 2018-02-03
Muscular Dystrophy
  Major Points: Introduction to DMD: Duchenne muscular dystrophy is a lethal X-linked recessive neuromuscular disorder caused by mutations in the dystrophin gene. It leads to progressive muscular damage, degeneration,
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Duchenne Muscular Dystrophy Report Summary

Author or authors of report : Maria Sofia Falzarano, Chiara Scotton, Chiara Passarelli, Alessandra Ferlini, Alessandra Ferlini,
Date of report : 2015-10-07
Muscular Dystrophy
  Introduction to DMD Duchenne muscular dystrophy (DMD) is an X-linked inherited neuromuscular disorder resulting from mutations in the dystrophin gene. The absence of the dystrophin protein leads to degeneration
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Novel stem cell and gene therapy in diabetic retinopathy, age related macular degeneration, and retinitis pigmentosa Report Summary

Author or authors of report : Parker E. Ludwig, S. Caleb Freeman, Adam C. Janot.
Date of report : 2019-02-13
Optic Nerve Atrophy
Major Points and Findings: Introduction and Background: Degenerative retinal diseases, such as diabetic retinopathy and macular degeneration, are leading causes of blindness in the developed world. Current therapies can slow
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Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials (Report Summary)

Author or authors of report : Sonia Labrador-Velandia, María Luz Alonso-Alonso, Sara Alvarez-Sanchez, Jorge González-Zamora, Irene Carretero-Barrio, José Carlos Pastor, Iván Fernandez-Bueno, and Girish Kumar Srivastava
Date of report : 2016-11-26
Optic Nerve Atrophy
The medical report titled "Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials" focuses on the potential of mesenchymal stem cells (MSCs) in treating
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Current Concept of Stem Cell Therapy for Spinal Cord Injury Report Summary

Author or authors of report : Sun Kyu Oh, Sang Ryong Jeon
Date of report : 2016-10-31
Spinal Cord Injury
Major Points and Findings: 1. Introduction and Background: Spinal cord injury (SCI) is a devastating condition that can lead to significant neurological deficits. The incidence of SCI is approximately 29.5
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Stem Cell Therapy for Spinal Cord Injury Report Summary

Author or authors of report : Liyi Huang, Chenying Fu, Feng Xiong, Chengqi He, Quan Wei
Date of report : 2021-02-09
Spinal Cord Injury
Major Points and Findings: Background: Traumatic spinal cord injury (SCI) leads to direct and indirect damage to neural tissues. This results in motor and sensory dysfunction, dystonia, and pathological reflexes,
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Verteporfin therapy of subfoveal choroidal neovascularization in patients with age-related macular degeneration: additional information regarding baseline lesion composition’s impact on vision outcomes Report Summary

Author or authors of report : Neil M Bressler, Jennifer Arnold, Mustapha Benchaboune, Mark S Blumenkranz, Gary E Fish, Evangelos S Gragoudas, Hilel Lewis, Ursula Schmidt-Erfurth, Jason S Slakter, Susan B Bressler, Kelly Manos, Yong Hao, Laurie Hayes, John Koester, Al Reaves, H Andrew
Date of report : 2002-11-01
Optic Nerve Atrophy
Objective and Methods: The study aimed to explore the influence of baseline lesion composition on vision outcomes in patients with AMD treated with verteporfin for subfoveal choroidal neovascularization (CNV). Patients
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Stem Cells Therapy for Spinal Cord Injury: An Overview of Clinical Trials Report Summary

Author or authors of report : Serena Silvestro, Placido Bramanti, Oriana Trubiani, Emanuela Mazzon,
Date of report : 2020-01-19
Spinal Cord Injury
  Types of Stem Cells for SCI Treatment: Neuronal Stem Cells: These cells can differentiate into neurons, oligodendrocytes, and astrocytes. They also secrete growth-promoting factors like Brain-Derived Neurotrophic Factor (BDNF),
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Anti-VEGF Treatment Strategies for Wet AMD Report Summary

Author or authors of report : Jaclyn L. Kovach, Stephen G. Schwartz, Harry W. Flynn, Jr, Ingrid U. Scott,
Date of report : 2012-02-28
Optic Nerve Atrophy
Major Points: Introduction to AMD: Age-related macular degeneration is a complex condition involving interactions between various biological factors that can lead to choroidal neovascularization (CNV). VEGF plays a crucial role
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Progress in Stem Cell Therapy for Spinal Cord Injury Report Summary

Author or authors of report : Liansheng Gao, Yucong Peng, Weilin Xu, Pingyou He, Tao Li, Xiaoyang Lu, Gao Chen,
Date of report : 2020-11-05
Spinal Cord Injury
Background: Spinal cord injury (SCI) is a severe neurological condition that predominantly affects young individuals, leading to high morbidity and disability rates. Despite its severity, there are limited effective treatments
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Visual function in patients with optic nerve pallor (optic atrophy) Report Summary

Author or authors of report : Christine A. DeWitt, Lenworth N. Johnson, Dana B. Schoenleber, Dean P. Hainsworth, and Richard W. Madsen
Date of report : 2003-05-01
Optic Nerve Atrophy
Abstract Summary: This research is a cross-sectional study that aimed to understand the relationship between the degree of optic nerve pallor, also known as optic atrophy, and visual function. The
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Rehabilitation of spinal cord injuries Report Summary

Author or authors of report : Kemal Nas, Levent Yazmalar, Volkan Şah, Abdulkadir Aydın, and Kadriye Öneş
Date of report : 2015-01-18
Spinal Cord Injury
h2>Abstract: Definition: Spinal cord injury (SCI) refers to the injury of the spinal cord ranging from the foramen magnum to the cauda equina, resulting from compulsion, incision, or contusion. Causes:
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Surgical decompression in acute spinal cord injury Report Summary

Author or authors of report : Yiping Li, Chandler L. Walker, Yi Ping Zhang, Christopher B. Shields, Xiao-Ming Xu
Date of report : 2014-02-01
Spinal Cord Injury
  Major Points and Findings: Objective: The primary goal of treatment in acute spinal cord injury (SCI) is to minimize secondary damage and promote neurological regeneration and functional recovery. The
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Traumatic Spinal Cord Injury Report Summary

Author or authors of report : Arsalan Alizadeh, Scott Matthew Dyck, and Soheila Karimi-Abdolrezaee
Date of report : 2019-03-22
Spinal Cord Injury
The report states that more than 90% of SCI cases are traumatic, caused by incidents such as traffic accidents, violence, sports, or falls. The clinical outcomes of SCI are highly
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Optic Atrophy Report Summary

Author or authors of report : Syed Shoeb Ahmad; Venkata M. Kanukollu.
Date of report : 2022-08-08
Optic Nerve Atrophy
Definition Optic atrophy is the hallmark of damage to the visual pathway, appearing as a pale disc on fundus examination. It is not a disease in itself but indicates damage
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Advances in stem cell therapy for spinal cord injury Report Summary

Author or authors of report : Andrea J. Mothe,Charles H. Tator
Date of report : 2012-11-01
Spinal Cord Injury
Introduction & Abstract: Spinal cord injury (SCI) is a severe condition with significant personal and societal implications. Currently, there's no effective treatment for the neurological deficits caused by major SCI.
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Cell Replacement Therapy for Retinal and Optic Nerve Diseases Report Summary

Author or authors of report : Rosa M. Coco-Martin, Salvador Pastor-Idoate, Jose Carlos Pastor
Date of report : 2021-06-11
Spina Bifida
  Key Findings The report highlights that RPCs, PSCs, and MSCs have already entered early-stage clinical trials. These cell types have shown the ability to differentiate into retinal pigment epithelium
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Improved Bowel Function in Patients with Spina Bifida After Bone Marrow-Derived Mononuclear Cell Transplantation: A Report of 2 Cases Report Summary

Author or authors of report : Nguyen Thanh Liem, Vu Duy Chinh, Nguyen Thi Thinh, Ngo Duy Minh,Hoang Minh Duc
Date of report : 2018-08-25
Spina Bifida
Background: Spina bifida (SB) is a common malformation due to neural tube defects. Children with SB often suffer from long-term functional disorders such as urinary dysfunction, bowel dysfunction, paraplegia, and
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Transamniotic mesenchymal stem cell therapy for neural tube defects preserves neural function through lesion-specific engraftment and regeneration Report Summary

Author or authors of report : Xiaowei Wei, Wei Ma, Hui Gu, Dan Liu, Wenting Luo, Yuzuo Bai, Weilin Wang, Vincent Chi Hang Lui, Peixin Yang, Zhengwei Yuan
Date of report : 2020-07-13
Spina Bifida
Background on NTDs: Neural tube defects (NTDs) are severe congenital anomalies that lead to prenatal mortality and lifelong morbidity. Current treatments, which involve surgical closure of NTD lesions, offer limited
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Sensory neuron differentiation potential of in utero mesenchymal stem cell transplantation in rat fetuses with spina bifida aperta Report Summary

Author or authors of report : Wei Ma, Xiaowei Wei, Hui Gu, Hui Li , Kaoping Guan, Dan Liu,Lizhu Chen,Songying Cao, Dong An, Henan Zhang, Tianchu Huang, Jianing Miao, Guifeng Zhao, Di Wu, Bo Liu, Weilin Wang, Zhengwei Yuan,
Date of report : 2015-07-14
Spina Bifida
  Methods: The study involved pregnant rats treated with retinoic acid on embryonic day 10 (E10). These rats underwent fetal surgery for MSC transplantation on embryonic day 16 (E16). The
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Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta Report Summary

Author or authors of report : Hui Li, Fei Gao, Lili Ma, Junhong Jiang, Jianing Miao, Mingyu Jiang, Yang Fan, Lili Wang, Di Wu, Bo Liu, Weilin Wang,Vincent Chi Hang Lui, Zhengwei Yuan
Date of report : 2012-06-28
Spina Bifida
Major Points and Findings: Objective: The study aimed to explore the therapeutic potential of prenatal transplantation of mesenchymal stem cells (MSCs) in rat foetuses diagnosed with spina bifida aperta, a
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Neural tube defects Report Summary

Author or authors of report : Dhara B Dhaulakhandi, Seema Rohilla, Kamal Nain Rattan
Date of report : 2010-07-31
Spina Bifida
Summary of Medical Report on Neural Tube Defects The medical report titled "Neural tube defects: review of experimental evidence on stem cell therapy and newer treatment options" focuses on the
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Efficacy and Safety of Stem Cell Therapy in Cerebral Palsy Report Summary

Author or authors of report : Jiayang Qu, Lin Zhou, Hao Zhang, Dongmiao Han, Yaolin Luo, Junming Chen, Lincai Li, Zhengwei Zou, Zhengyi He, Minhong Zhang, Junsong Ye
Date of report : 2022-12-14
Cerebral Palsy
Major Points and Findings: Aim: The study aimed to assess the efficacy and safety of stem cell therapy for cerebral palsy. Although previous studies have shown the potential benefits of
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Autologous Cord Blood in Children with Cerebral Palsy Report Summary

Author or authors of report : Dariusz Boruczkowski, Josep-Maria Pujal, Izabela Zdolińska-Malinowska,
Date of report : 2019-05-16
Cerebral Palsy
Major Points and Findings: Objective: The review aims to present the current understanding of the clinical use of umbilical cord blood based on articles from PubMed and clinical trials registered
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Spina Bifida Report Summary

Author or authors of report : Abd-Elrahman Said Hassan, Yimeng Lina Du, Su Yeon Lee, Aijun Wang, Diana Lee Farmer,
Date of report : 2022-06-06
Spina Bifida
Definition and Prevalence: Spina bifida is recognized as the most common congenital defect of the central nervous system. Individuals with this condition can face lifelong disabilities. Genetic and Molecular Understanding:
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Spina Bifida—A Multidisciplinary Perspective Report Summary

Author or authors of report : Jack M. Fletcher, Timothy J. Brei,
Date of report : 2011-03-01
Spina Bifida
  Introduction: Spina Bifida—A Multidisciplinary Perspective Major Points and Findings Nature of Spina Bifida: Spina bifida is the most common birth defect affecting the central nervous system (CNS). It is
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Efficacy and safety of stem cell therapy in cerebral palsy Report Summary

Author or authors of report : Jiayang Qu, Lin Zhou, Hao Zhang, Dongmiao Han, Yaolin Luo, Junming Chen,Lincai Li, Zhengwei Zou, Minhong Zhang, Junsong Ye
Date of report : 2022-12-14
Spina Bifida
  Major Points: The report is a meta-analysis that aims to evaluate the effectiveness and safety of stem cell therapy (SCT) for cerebral palsy (CP). A total of 798 articles
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Cerebral Palsy Report Summary

Author or authors of report : Mayo Clinic Staff
Date of report : 2021-09-01
Cerebral Palsy
Mayo Clinic
Cerebral palsy - Diagnosis and treatment Diagnosis: Signs and symptoms of cerebral palsy can become more apparent over time, often not diagnosed until a few months to a year after
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Treatment of Spinal Muscolar Atrophy with Intrathecal Mesenchymal Cells

Author or authors of report : Marino Andolina
Date of report : 2012-05-05
Spinal Muscular Atrophy (SMA)
Background and Objectives: SMA1 is a genetic disease causing progressive apoptosis of the second motoneuron, leading to complete paralysis. Given the reported efficacy of mesenchymal cells in treating other neurological
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Cerebral Palsy Report Summary

Author or authors of report : Mayo Clinic Staff
Date of report : 2021-09-01
Cerebral Palsy
Mayo clinic
Major Points: Causes: Cerebral palsy is caused by an abnormality or disruption in brain development, usually before a child is born. Factors that can lead to problems with brain development
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Improvement by Human Oligodendrocyte Progenitor Cells of Neurobehavioral Disorders in an Experimental Model of Neonatal Periventricular Leukomalacia Report Summary

Author or authors of report : Tae-Kyun Kim, Dongsun Park, Young-Hwan Ban, Yeseul Cha, Eun Suk An, Jieun Choi, Ehn-Kyoung Choi, Yun-Bae Kim,
Date of report : 2018-07-06
Cerebral Palsy
Major Points and Findings: Objective: The study aimed to understand the potential benefits of F3.olig2 cells in improving neurobehavioral deficits in a model of PVL. Methodology: Seven-day-old male rats were
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Stem cell model of spinal muscular atrophy Report Summary

Author or authors of report : Allison D. Ebert, Clive N. Svendsen,
Date of report : 2011-07-21
Spinal Muscular Atrophy (SMA)
Major Points and Findings: Introduction to Stem Cells: Human embryonic stem cells (hESCs) are a valuable resource for studying human development and diseases. However, their use is limited due to
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Is Stem Cell Therapy the New Savior for Cerebral Palsy Patients? Report Summary

Author or authors of report : Varun Vankeshwaram, Ankush Maheshwary, Divya Mohite, Janet A Omole, and Safeera Khan,
Date of report : 2020-09-02
Cerebral Palsy
Background on Cerebral Palsy (CP): CP is a leading cause of childhood motor disability, affecting the individual's development and ability to function. Factors contributing to CP include preterm delivery, low
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Restoring SMN Expression Report Summary

Author or authors of report : Tejal Aslesh, Toshifumi Yokota
Date of report : 2022-01-26
Spinal Muscular Atrophy (SMA)
Introduction to SMA: Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disorder and is one of the leading genetic causes of infant mortality. The disease manifests as progressive muscle
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Stem Cell Treatment and Cerebral Palsy Report Summary

Author or authors of report : Simone Eggenberger, Céline Boucard, Andreina Schoeberlein, Raphael Guzman, Andreas Limacher, Daniel Surbek, and Martin Mueller
Date of report : 2019-10-26
Cerebral Palsy
Major Points and Findings: Background: Cerebral palsy (CP) is a severe motor disability that can result from perinatal complications. It is a non-progressive disease with a prevalence of 1-2 per
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Advances in modeling and treating spinal muscular atrophy Report Summary

Author or authors of report : Meaghan Van Alstyne, Livio Pellizzoni
Date of report : 2017-10-01
Spinal Muscular Atrophy (SMA)
  Purpose of Review SMA is an inherited neurodegenerative disorder that manifests in childhood. It is caused by a deficiency of the survival motor neuron (SMN) protein. This deficiency leads
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Progress in clinical trials of stem cell therapy for cerebral palsy Report Summary

Author or authors of report : Zhong-Yue Lv, Ying Li, Jing Liu
Date of report : 2020-12-12
Cerebral Palsy
Introduction: CP is a set of permanent movement and posture development disorders, often accompanied by other disturbances like sensation, perception, cognition, communication, behavior, epilepsy, and secondary musculoskeletal problems. The global
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The Role of Stem Cells in the Treatment of Cerebral Palsy Report Summary

Author or authors of report : Anahita Kiasatdolatabadi, Nasrin Lotfibakhshaiesh, Meysam Yazdankhah,Somayeh Ebrahimi-Barough,Mina Jafarabadi,Arman Ai,Esmaeil Sadroddiny,Jafar Ai,
Date of report : 2016-08-13
Cerebral Palsy
Introduction to Cerebral Palsy (CP): Cerebral palsy is a neuromuscular disease resulting from an injury to an infant's brain. This disorder leads to various neurological dysfunctions in the affected individual.
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Spinal Muscular Atrophy Report Summary

Author or authors of report : Stephen J. Kolb, M.D, John T. Kissel, M.D.,
Date of report : 2016-11-01
Spinal Muscular Atrophy (SMA)
Spinal Muscular Atrophy (SMA) Authors: Stephen J. Kolb, M.D., Ph.D., and John T. Kissel, M.D. Affiliation: Department of Neurology and Department of Biological Chemistry and Pharmacology, The Ohio State University
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A Review on Recent Advances of Cerebral Palsy Report Summary

Author or authors of report : Sudip Paul, Anjuman Nahar, Mrinalini Bhagawati, Ajaya Jang Kunwar,
Date of report : 2022-07-30
Cerebral Palsy
Major Points and Findings: Objective: The narrative review aims to summarize the latest advances in cerebral palsy (CP) and identify areas where more research is required. Prevalence and Risk Factors:
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Spinal Muscular Atrophy Report summary

Author or authors of report : W. David Arnold, Darine Kassar, John T. Kissel,
Date of report : 2014-12-16
Spinal muscular atrophy
Introduction to SMA: SMA is a group of disorders associated with spinal motor neuron loss. The most common form of SMA is proximal or 5q SMA. Historically, diagnosis was based
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Cerebral Palsy in Children Reprot Summary

Author or authors of report : Dilip R. Patel, Mekala Neelakantan, Karan Pandher, Joav Merrick,
Date of report : 2020-02-09
Cerebral Palsy
Definition and Characteristics Cerebral palsy (CP) is a disorder characterized by abnormal tone, posture, and movement. It is clinically classified based on the predominant motor syndrome, including spastic hemiplegia, spastic
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Effect of stem cell treatment on functional recovery of spinocerebellar Ataxia Report Summary

Author or authors of report : Pablo Andrei Appelt, Kristin Comella, Luciane Aparecida Pascucci Sande de Souza & Gustavo José Luvizutto
Date of report : 2021-02-25
Ataxia
Major Points: Background: SCA is characterized by changes in balance, locomotion, and motor coordination. Stem cell therapies are being explored as a potential treatment to delay the disease's progression. Objectives:
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Spina Bifida Report Summary

Author or authors of report : Andrew J. Copp, N. Scott Adzick, Lyn S. Chitty, Jack M. Fletcher, Grayson N. Holmbeck, Gary M. Shaw,
Date of report : 2015-04-30
Spina Bifida
Spina Bifida: Spina bifida is a birth defect where the vertebral column is open, often involving the spinal cord. The most clinically significant form is myelomeningocele (MMC; open spina bifida),
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Pre-emptive Allogeneic Hematopoietic Stem Cell Transplantation in Ataxia Telangiectasia Report Summary

Author or authors of report : Shahrzad Bakhtiar Sandra Woelke Sabine Huenecke Matthias Kieslich Alexander Malcolm Taylor Ralf Schubert Stefan Zielen Peter Bader
Date of report : 2018-10-19
Ataxia
Key Findings: Immune Reconstitution: The patient showed rapid and stable engraftment by day +15 post-transplantation. The T-cell lymphopenia was corrected, and there was an increase in serum immunoglobulins, particularly IgA
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Treatment of Spinocerebellar Ataxia with Mesenchymal Stem Cells Report Summary

Author or authors of report : Yun-An Tsai, Ren-Shyan Liu, Jiing-Feng Lirng, Bang-Hung Yang, Chin-Hao Chang, Yi-Chen Wang, Yu-Shan Wu, Jennifer Hui-Chun Ho, Oscar K. Lee, and Bing-Wen Soong
Date of report : 2017-03-01
Ataxia
Major Points: Objective: The primary aim was to assess the safety and tolerability of intravenous MSCs, and secondarily, to evaluate their potential efficacy in treating SCA. Methodology: The study was
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Ataxia Report Summary – Hafiz S, De Jesus O

Author or authors of report : Hafiz S, De Jesus O
Date of report : 2020-09-24
Ataxia
Types and Causes Ataxia is categorized into three types based on location: cerebellar, sensory, and vestibular. It can also be subdivided into sporadic (no family history, manifests in adulthood), hereditary
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Ataxia Report Summary – Sheng-Han Kuo

Author or authors of report : Sheng-Han Kuo
Date of report : 2019-08-25
Ataxia
Major Points and Findings: Purpose of Review: The article aims to provide a comprehensive review of cerebellar ataxia, focusing on its symptoms, diagnostic methods, genetics, and management. Recent Findings: Advancements
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Ataxia Report Summary – Mayo Clinic Staff

Author or authors of report : Mayo Clinic Staff
Date of report : 2022-08-09
Ataxia
Mayo Clinic
Causes Ataxia can be caused by a wide range of factors, including: Alcohol misuse Stroke Brain tumors Multiple sclerosis Certain medications Genetic disorders The report categorizes the causes into three
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Spinocerebellar Ataxia Report Summary

Author or authors of report : Jenish Bhandari, Pawan K Thada, and Debopam Samanta
Date of report : 2023-08-08
Ataxia
The medical report focuses on Spinocerebellar Ataxia (SCA), a rare, inherited, progressive neurodegenerative disease that primarily affects the cerebellum. The condition is characterized by the absence of voluntary muscle coordination,
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Ataxia Report Summary

Author or authors of report : National Health Service
Date of report : 2021-04-16
Ataxia
National Health Service
Types of Ataxia The NHS report categorizes ataxia into three broad types: Acquired Ataxia: This type develops due to external factors such as trauma, stroke, multiple sclerosis, brain tumors, or
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Ataxia Report Summary

Author or authors of report : Tetsuo Ashizawa, FAAN and Guangbin Xia
Date of report : 2016-08-22
Ataxia
Purpose and Summary: The article aims to introduce the background and common causes of ataxia and offers a general approach to assessing and managing patients with this condition. Clinicians are
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Transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells in autism Report Summary

Author or authors of report : Yong-Tao Lv, Yun Zhang, Min Liu, Jia-na-ti Qiuwaxi, Paul Ashwood, Sungho Charles Cho, Ying Huan, Ru-Cun Ge, Xing-Wang Chen, Zhao-Jing Wang, Byung-Jo Kim & Xiang Hu
Date of report : 2013-08-27
Autism
Background: Autism is a pervasive neurodevelopmental disorder with no defined mechanisms of pathogenesis, and therapy is mostly limited to behavioral interventions. Stem cell transplantation may offer a unique treatment strategy
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Autologous Cord Blood Infusions Are Safe and Feasible in Young Children with Autism Spectrum Disorder Report Summary

Author or authors of report : Geraldine Dawson, Jessica M. Sun, Katherine S. Davlantis, Michael Murias, Lauren Franz, Jesse Troy,Ryan Simmons, Maura Sabatos‐DeVito, Rebecca Durham and Joanne Kurtzberg,
Date of report : 2017-04-05
Autism
Major Points and Findings: Objective: The study aimed to explore the safety, feasibility, and potential benefits of a single intravenous infusion of autologous umbilical cord blood in young children diagnosed
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Autologous bone marrow mononuclear cell therapy for autism: an open label proof of concept study Report Summary

Author or authors of report : Alok Sharma, Nandini Gokulchandran, Hemangi Sane, Anjana Nagrajan, Amruta Paranjape, Pooja Kulkarni, Akshata Shetty, Priti Mishra, Mrudula Kali, Hema Biju and Prerna Badhe
Date of report : 2013-08-25
Autism
Major Points and Findings: Background: Cellular therapy is emerging as a potential treatment for autism. The primary pathogenetic mechanisms of autism are believed to be hypoperfusion (reduced blood flow) and
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Dietary interventions for autism spectrum disorder: An updated systematic review of human studies Report Summary

Author or authors of report : Cecilia N Amadi, Chinna N Orish, Chiara Frazzoli and Orish E Orisakwe,
Date of report : 2022-09-19
Autism
Background: Autism is a multifaceted spectrum of disorders with origins rooted in genetics, epigenetics, autoimmune responses, oxidative stress, and environmental factors. Using dietary approaches to treat ASD is gaining traction
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Comprehensive Management of Autism: Current Evidence Report Summary

Author or authors of report : Manjiri Deshpande Shenoy, Vishal Indla, and Harish Reddy.
Date of report : 2017-12-01
Autism
Comprehensive Management of Autism: Current Evidence The article titled "Comprehensive Management of Autism: Current Evidence" from the Indian Journal of Psychological Medicine (Nov-Dec 2017) by Manjiri Deshpande Shenoy, Vishal India,
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Autism medical comorbidities Report Summary

Author or authors of report : Mohammed Al-Beltagi
Date of report : 2021-05-09
Autism
Autism Medical Comorbidities The medical report from the "World J Clin Pediatr" titled "Autism medical comorbidities" is authored by Mohammed Al-Beltagi. The report delves into the various medical comorbidities that
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Efficacy and Safety of Stem Cell Therapy in Children With Autism Spectrum Disorders: A Systematic Review and Meta-Analysis Rport Summary

Author or authors of report : Jiayang Qu, Zicai Liu, Lincai Li, Zhengwei Zou, Zhengyi He, Lin Zhou, Yaolin Luo, Minhong Zhang, and Junsong Ye.
Date of report : 2022-05-04
Autism
Major Points and Findings: Aim: The study aimed to gather evidence regarding the efficacy and safety of stem cell therapy for autism spectrum disorders (ASD) in children. The authors conducted
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Autism Spectrum Disorders: Diagnosis and Treatment Report Summary

Author or authors of report : Ronan Lordan, Cristiano Storni, and Chiara Alessia De Benedictis
Date of report : 2021-08-20
Autism
Abstract: The diagnostic criteria and treatment approaches for autism spectrum disorders (ASD) have evolved significantly over time. Diagnosis is primarily based on observational screening tools assessing a child's social and
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