Summary
Diagnosis
Sex
Age
Nationality
Optic Nerve Hypoplasia (ONH) / Septooptic Dysplasia (SOD)
Female
16 months
Irish
Injections
Cell type
Admission date
Discharge date
8
2011-01-16
2011-03-01
Condition On Admission
The patient had bilateral vision deterioration and a development delay since she was 5 months old. On physical examination her eyeballs were normal and pupils were equal and reactive to light. She could recognize light and darkness. Nystagmus was present. She could not look at objects and mostly let her head hang down to the floor when sitting.
Treatment Schedule
The patient received 8 umbilical cord-derived mesenchymal stem cell (UCMSC) packets by intravenous (IV) injections as per the schedule below:
Number
Date
Cell Type
Delivery Method
Side Effects
1
2011-01-19
none reported
2
2011-01-21
none reported
3
2011-01-24
none reported
4
2011-01-28
none reported
5
2011-02-11
none reported
6
2011-02-16
none reported
7
2011-02-21
none reported
8
2011-02-25
none reported
Condition at discharge
Stem cell treatment was completed without any adverse events or side effects. At the end of the treatment period the patient was able to reach out and grasp objects 50cm in front of her and track light with her eyes. There was also a decrease in the nystagmus.
Condition 1 month after treatment
One month after their daughter’s treatment the parents completed a Beike follow-up survey and in this survey they reported that their daughter had made significant progress in her physical condition and that her quality of life had significantly improved. At the time they also felt that new improvements were still being made by their daughter.
Condition 12 months after treatment
Please see an excerpt from the patient’s 12 month assessment below:
Symptom
Parents’ Assessment of Improvement
Blindness
Significant improvement
Light perception
Significant improvement
Ability to see hand movement
Significant improvement
Vision in left eye
Significant improvement
Vision in right eye
Significant improvement
Night vision
Significant improvement
Ability to see things at a close distance
Significant improvement
Nystagmus
Significant improvement
Strabismus
Significant improvement
