Summary
Diagnosis
Sex
Age
Nationality
Optic Nerve Hypoplasia (ONH) / Septooptic Dysplasia (SOD)
Female
2 years
USA
Injections
Cell type
Admission date
Discharge date
7
2011-06-21
2011-07-11
Condition On Admission
The patient was admitted for treatment for her vision problem. Physical examination showed the movement of her eyeballs was good. Spontaneous nystagmus was present. Her pupils were normal in shape and reactive to light. The patient could differentiate between light and dark. Eye tests could not be conducted due to her young age; therefore it was difficult to confirm her exact visual acuity. The other tests after admission showed no significant abnormalities.
Treatment Schedule
The patient received 7 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV) injections as per schedule below:
Number
Date
Cell Type
Delivery Method
Side Effects
1
2011-06-24
none reported
2
2011-06-27
Intravenous Injection &
Intravenous Injection
none reported
3
2011-07-01
Intravenous Injection &
Intravenous Injection
none reported
4
2011-07-04
Intravenous Injection &
Intravenous Injection
none reported
Condition at discharge
After treatment the doctors noted the patient could track light with her right eye and the frequency of nystagmus had reduced. The family were pleased with the improvements their daughter had gained during the treatment, especially the improvements in her vision. They also reported at the time of discharge that her bowel function had also improved. The patient was now having a daily bowel movement, whereas prior to treatment it was every 2 or 3 days.
Symptom
Parents’ Assessment of Improvement
Light perception
Moderate improvement
Vision in left eye
Small improvement
Vision in right eye
Moderate improvement
Ability to see things clearly
Small improvement
Ability to focus eyes quickly
Small improvement
Ability to keep eyes focused for a long time
Moderate improvement
Ability to see things at a far distance
Small improvement
Nystagmus (uncontrolled eye movement)
Small improvement
Condition 3 months after treatment
The parents completed the Beike follow-up survey three months after the treatment. They were pleased with the improvements the treatment had given their daughter for both her physical condition and quality of life. In addition to the improvements in the symptoms listed below, the parents felt their daughter had more confidence to move around. Below is an excerpt from the parent’s completed 3-month follow-up survey:
Symptom
Parents’ Assessment of Improvement
Blindness
Moderate improvement
Light perception
Moderate improvement
Ability to see hand movement
Significant improvement
Able to count fingers
Significant improvement
Vision in left eye
Significant improvement
Vision in right eye
Small improvement
Color Vision
Small improvement
Night vision
Small improvement
Ability to see things clearly
Significant improvement
Ability to focus eyes quickly
Significant improvement
Ability to keep eyes focused for a long time
Significant improvement
Ability to see things at a close distance
Moderate improvement
Ability to see things at a far distance
Significant improvement
Nystagmus (uncontrolled eye movement)
Significant improvement
Condition 12 months after treatment
The parents also completed a Beike follow-up survey one year after their daughter’s treatment. They were satisfied with the outcome of the treatment and felt their daughter had made significant improvements in her quality of life and had further improved in her overall physical condition. Below is an excerpt from the parent’s completed 1 year follow-up survey:
Symptom
Parents’ Assessment of Improvement
Blindness
Significant improvement
Light perception
Moderate improvement
Ability to see hand movement
Moderate improvement
Able to count fingers
Significant improvement
Vision in left eye
Significant improvement
Vision in right eye
Small improvement
Visual field
Small improvement
Color Vision
Significant improvement
Night vision
Small improvement
Ability to see things clearly
Moderate improvement
Ability to focus eyes quickly
Small improvement
Ability to keep eyes focused for a long time
Moderate improvement
Ability to see things at a close distance
Moderate improvement
Ability to see things at a far distance
Small improvement
Nystagmus (uncontrolled eye movement)
Significant improvement
