Summary
| Diagnosis | Sex | Age | Nationality |
|---|---|---|---|
| Cerebral Palsy | Male | 3 years | USA |
| Injections | Cell type | Admission date | Discharge date |
|---|---|---|---|
| 9 | UCMSC | June 12th 2022 | July 4th 2022 |
Medical history
The patient, a male born in 2017 in California, USA was diagnosed with mild cerebral palsy (CP) on March 23, 2019, after experiencing developmental delays since infancy, including difficulties with speech and motor skills. Initially, his condition was mistaken for autism spectrum disorder, leading to therapy interventions that did not yield significant improvements. Despite therapeutic efforts, including speech and occupational therapy, his speech remained impaired. The patient’s medical history reveals no significant family medical issues, except for a twin sister who did not experience developmental delays.
Condition On Admission
The patient presents with significant speech impairment, characterized by the ability to only speak 3 to 5 words. He also exhibits a lazy left eye, slow motor skills, difficulty grasping objects firmly, and inward-facing toe fingers, affecting his mobility. Despite understanding verbal commands, he struggles with writing and maintaining eye contact for extended periods. The patient finds solace in water activities and enjoys watching cartoons on his iPhone. Although he has learned some sign language for communication, his ability to articulate verbally remains severely limited. The family is hoping for improved speech and overall developmental outcomes.
Treatment Schedule
Patient received 9 packs of umbilical cord derived stem cell (UCMSC) by intravenous (IV) injection and intrathecal injection via lumbar puncture (LP), as per the schedule below:
| Number | Date | Cell Type | Delivery Method | Side Effects |
|---|---|---|---|---|
| 1 | 2022-06-16 | UCMSC | Intrathecal Injection & Intravenous Injection | none reported |
| 2 | 2022-06-20 | UCMSC | Intrathecal Injection | none reported |
| 3 | 2022-06-23 | UCMSC | Intrathecal Injection & Intravenous Injection | none reported |
| 4 | 2022-06-24 | UCMSC | Intrathecal Injection | none reported |
| 5 | 2022-06-30 | UCMSC | Intrathecal Injection & Intravenous Injection | none reported |
| 6 | 2022-07-04 | UCMSC | Intrathecal Injection | none reported |
Condition at discharge
The patient’s stem cell treatment has shown general moderate improvements in physical condition, notably with a little more eye contact and a slightly improved quality of life, as reported by the parents. Although the doctor did not confirm improvements, the family remains satisfied with the treatment outcome. Regarding specific symptoms, there have been small improvements in balance, drooling, involuntary movements, learning disability, limb muscle strength, range of movement, spasticity, speech (babbling for infants), standing up, swallowing, and trunk muscle strength.
| Symptom | Parents’ Assessment of Improvement |
|---|---|
| Balance | Small improvement |
| Drooling | Small improvement |
| Involuntary movements | Small improvement |
| Learning disability | Small improvement |
| Limb muscle strength | Small improvement |
| Range of movement | Small improvement |
| Spasticity | Small improvement |
| Speech (babbling for infants) | Small improvement |
| Standing up | Small improvement |
| Swallowing | Small improvement |
| Trunk muscle strength | Small improvement |
Condition 6 months after treatment
Six months after undergoing stem cell treatment, the patient has shown general moderate improvements in physical condition, with increased activity levels and a moderately improved quality of life, as reported by the parents. The patient appears more alert, follows directions, and engages in running games more frequently. However, the doctor did not confirm these improvements, yet the family remains satisfied with the treatment outcome. Notably, there have been moderate improvements in balance, learning disability, and range of movement, along with small improvements in appetite, drooling, limb muscle strength, mood disorder, spasticity, speech, swallowing, and trunk muscle strength.
| Symptom | Parents’ Assessment of Improvement |
|---|---|
| Balance | Moderate improvement |
| Learning disability | Moderate improvement |
| Range of movement | Moderate improvement |
| Appetite | Small improvement |
| Drooling | Small improvement |
| Limb muscle strength | Small improvement |
| Mood disorder | Small improvement |
| Spasticity | Small improvement |
| Speech (babbling for infants) | Small improvement |
| Swallowing | Small improvement |
| Trunk muscle strength | Small improvement |
