Summary
Diagnosis
Sex
Age
Nationality
Traumatic Brain Injury
Female
46 years
Brazil
Injections
Cell type
Admission date
Discharge date
7
2018-07-09
2018-08-02
Condition On Admission
The patient’s chief complaint was of weakness in all four limbs for more than 20 years. Patient first noted he had a weakness in both his upper limbs in 1987, which was especially evident in his handwriting. The weakness progressively got worse over time. In 1994, he noticed he had problems walking up and down stairs and would trip over himself from time to time; an MRI confirmed a diagnosis of Ataxia. On physical assessment upon hospital admission he was found to have low muscle tone in all limbs with muscle power of 5/5. Coordination tests such as finger-to-nose and heel-to-tibia showed poor coordination and the patient was unable to walk heel-to-toe. Routine examination showed no other abnormalities.
Treatment Schedule
Patient received 6 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV) injection and lumbar puncture (LP), as per the schedule below:
Number
Date
Cell Type
Delivery Method
Side Effects
1
2018-07-13
none reported
2
2018-07-17
none reported
3
2018-07-20
none reported
4
2018-07-23
none reported
5
2018-07-27
none reported
6
2018-07-31
Intrathecal Injection &
Intravenous Injection
none reported
Condition 1 month after treatment
Condition 1 months after treatment: The patient reported significant improvements at one month after his treatment. He stated, “[I] can walk heel to toe, can do the balancing exercise for longer periods of time, can go up and down stairs with no hands.” He also made comments about the importance of continuing to do daily exercise and how it is becoming easier but also feels that the exercises are essential to aiding his continued improvements.
Condition 12 months after treatment
Condition 12 months after treatment: At the 12 month follow up point the patient reported that he was satisfied with the outcome of his treatment which has improved his quality of life and given him moderate improvements overall in his physical condition.
Symptom
Parents’ Assessment of Improvement
Balance
Moderate improvements
Coordination
Moderate improvements
Fine hand movements
Small improvements
Tremors
Not applicable
Control of movement
Moderate improvements
Muscle stiffness
Not applicable
Speech
Moderate improvements
Walking
Moderate improvements
Fatigue
Small improvements
