Last Updated on: 4th September 2024, 05:12 pm
Summary
Diagnosis | Sex | Age | Nationality |
---|---|---|---|
Cerebral Palsy | Male | 9 months | Romania |
Injections | Cell type | Admission date | Discharge date |
8 | UCMSC | February 5th 2022 | February 27th 2022 |
Medical history
The patient, a male infant born in May 2020, has a complex medical history. He was diagnosed with ALCAPA heart malformation, which was surgically repaired in September 2020. However, he also suffered from a stroke around the same time, leading to symptomatic epilepsy and partial optic nerve atrophy suspicion. Following the surgical intervention, he experienced seizures and was treated with antiepileptic drugs, yet his condition remained drug-resistant, with daily seizures affecting his cardiac health. His heart function, currently at an ejection fraction of 20%, poses limitations on treatment options due to sedation contraindications. Medications for heart function, diuresis, and epilepsy have been ongoing since his diagnosis, with adjustments made to manage his symptoms.
Condition On Admission
The patient’s current symptoms include daily seizures with varying intensity and duration, despite medication adjustments and hospitalization. The seizures, characterized by spasms, occur 3-5 times a day and last for 3-5 minutes each. His neurological condition presents challenges, with suspicions of partial optic nerve atrophy, moderate-severe brain atrophy, and diffuse lesions noted in MRI scans. While his cardiac and pulmonary status are stable, his heart function remains compromised, affecting the choice of treatment strategies. Concerns about visual perception delay and the impact of medication on his optic nerve add complexity to his medical management. Despite ongoing evaluations and treatments, the family seeks interventions aimed at stopping seizures, improving neurological function, vision, and heart health.
Treatment Schedule
Patient received 8 packs of umbilical cord derived stem cell (UCMSC) by intravenous (IV) injection and intrathecal injection via lumbar puncture (LP), as per the schedule below:
Number | Date | Cell Type | Delivery Method | Side Effects |
---|---|---|---|---|
1 | 2022-02-10 | UCMSC | Intrathecal Injection & Intravenous Injection |
none reported |
2 | 2022-02-14 | UCMSC | Intrathecal Injection & Intravenous Injection |
none reported |
3 | 2022-02-17 | UCMSC | Intrathecal Injection & Intravenous Injection |
none reported |
4 | 2022-02-21 | UCMSC | Intrathecal Injection | none reported |
5 | 2022-02-24 | UCMSC | Intrathecal Injection | none reported |
Condition at discharge
Symptom | Parents’ Assessment of Improvement |
---|---|
Appetite | Significant improvement |
Head control | Small improvement |
Range of movement | Small improvement |
Condition 3 months after treatment
Three months after treatment, the patient’s condition has seen significant setbacks. The general physical condition has not improved, and neither has the quality of life, according to the parents. Stem cell treatment did not yield confirmable improvements, leaving them dissatisfied with the outcome. Additionally, the patient required Depakine as an additional treatment due to a retriggering of epilepsy by the stem cells. Notably, certain symptoms have worsened since treatment, including head control, limb muscle strength, and range of movement.
Symptom | Parents’ Assessment of Improvement |
---|---|
Head control | Worse than before treatment |
Limb muscle strength | Worse than before treatment |
Range of movement | Worse than before treatment |
Bladder control | Normal function |
Condition 12 months after treatment
After twelve months post-treatment, the patient’s general physical condition has moderately improved, although the stem cell treatment did not enhance their quality of life as perceived by the parents. There were small improvements noted in balance, head control, involuntary movements, and range of movement. Certain symptoms remained unchanged, such as bladder control and crawling, while drooling showed no improvement and appetite and muscle strength showed moderate and significant improvements.
Symptom | Parents’ Assessment of Improvement |
---|---|
Appetite | Moderate improvement |
Balance | Small improvement |
Head control | Small improvement |
Involuntary movements | Small improvement |
Limb muscle strength | Significant improvement |
Babbling | Moderate improvement |
Standing up | Moderate improvement |
Swallowing | Moderate improvement |
Trunk muscle strength | Moderate improvement |