Stem Cell Medical Reports Archive

Author or authors of report : Kasidit Kasitipradit, Surangrat Thongkorn, Songphon Kanlayaprasit, Thanit Saeliw, Pattanachat Lertpeerapan, Pawinee Panjabud, Depicha Jindatip, Valerie W. Hu, Takako Kikkawa, Noriko Osumi, Tewarit Sarachana

Date of report : 2025-01-01

Medical conditions :

Autism

Report Commissioned By :

Chulalongkorn University (Thailand), George Washington University (USA), Tohoku University (Japan)

Summary This study, titled “Sex-specific effects of prenatal bisphenol A exposure on transcriptome-interactome profiles of autism candidate genes in neural stem cells from offspring hippocampus”, investigates how prenatal exposure to

Allogeneic Mesenchymal Stem Cell Therapy with Laromestrocel in Alzheimer’s Disease: A Phase 2a Trial

Author or authors of report : Brian G. Rash, Kevin N. Ramdas, Anthony A. Oliva Jr.

Date of report : 2025-03-10

Medical conditions :

Alzheimer's Disease

Report Commissioned By :

Nature Medicine

Summary of the Main Points/Findings Background and Objective: This randomized, double-blind, placebo-controlled, parallel-group phase 2a clinical trial aimed to assess the safety and efficacy of laromestrocel, a bone-marrow-derived allogeneic mesenchymal

Pre-clinical Safety and Efficacy of Human Induced Pluripotent Stem Cell-Derived Midbrain Dopaminergic Progenitor Cells for Parkinson’s Disease

Author or authors of report : Jeha Jeon, Young Cha, Yean Ju Hong, In-Hee Lee, Heejin Jang, Sanghyeok Ko, Serhiy Naumenko, Minseon Kim, Hannah L. Ryu, Zenith Shrestha, Nayeon Lee, Tae-Yoon Park, HoeWon Park, Seo-Hyun Kim

Date of report : 2025-03-06

Medical conditions :

Parkinsons

Report Commissioned By :

Cell Stem Cell

Summary of the Main Points/Findings: Background and Objective: This preclinical study aimed to assess the safety, quality, and functional potential of midbrain dopaminergic progenitor cells derived from patient-specific human induced

Industry Updates from the Field of Stem Cell Research and Regenerative Medicine November 2024 (Summary)

Author or authors of report : Dusko Ilic and Mirjana Liovic

Date of report : 2025-01-19

Medical conditions :

Autoimmune Disorder, Cancer, Degenerative Disease

Report Commissioned By :

Regenerative Medicine Journal (Taylor & Francis Group)

Summary of the Main Points/Findings Background and Objective: This report offers a curated overview of major commercial and scientific developments within the field of stem cell research and regenerative medicine

Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A

Author or authors of report : Alok Srivastava, M.D., Aby Abraham, D.M., Fouzia Aboobacker, D.M., Gurbind Singh, Ph.D., Tulasi Geevar, M.D., Uday Kulkarni, D.M., Sushil Selvarajan, D.M. , Trent Spencer, Ph.D.

Date of report : 2024-12-09

Medical conditions :

Hemophilia

Report Commissioned By :

New England Journal of Medicine

Summary of the Main Points/Findings Background and Objective: This single-center study aimed to evaluate the safety and efficacy of autologous CD34+ hematopoietic stem cells (HSCs) transduced with a lentiviral vector

Allogeneic Umbilical Cord-Derived Mesenchymal Stromal Cells in Severe Systemic Lupus Erythematosus: A Phase 1 Trial

Author or authors of report : Prof Dominique Farge, MD, Lucie Biard, PhDd, Ben Weil, EngDe, Virginie Girault, PhD, Pauline Lansiaux, PhD, Ingrid Munia, MS, Séverine Loisel, PhD, Catney Charles, BSca, Judikael Saout, PhD

Date of report : 2024-12-17

Medical conditions :

Lupus (SLE)

Report Commissioned By :

Fondation du Rein, ANR eCellFrance

Summary of the Main Points/Findings Background and Objective: This phase 1, dose-escalation trial aimed to assess the safety and preliminary efficacy of allogeneic umbilical cord-derived mesenchymal stromal cells (UC-MSCs) in

Induced Pluripotent Stem-Cell-Derived Corneal Epithelium for Transplant Surgery

Author or authors of report : Takeshi Soma, MDa, Yoshinori Oie, MDa, Hiroshi Takayanagi, MSa, Shoko Matsubara, BA, Tomomi Yamada, PhDd, Masaki Nomura, PhD

Date of report : 2024-11-16

Medical conditions :

Corneal Degeneration

Report Commissioned By :

The Lancet

Summary of the Main Points/Findings: Background and Objective: This single-arm, open-label, first-in-human interventional study in Japan aimed to assess the safety and feasibility of transplanting induced pluripotent stem-cell-derived corneal epithelium

Creating Functional Hematopoietic Stem Cells from iPS Cells for Blood Disorders and Beyond (Report summary)

Author or authors of report : Elizabeth S. Ng, Gulcan Sarila, Jacky Y. Li, Hasindu S. Edirisinghe, Ritika Saxena, Shicheng Sun, Freya F. Bruveris, Tanya Labonne, Nerida Sleebs, Alexander Maytum, Raymond Y. Yow, Chantelle Inguanti, Ali Motazedian, Vincenzo Calvanese, Sandra Capellera-G

Date of report : 2024-09-02

Medical conditions :

Diabetes, Spinal Cord Injury

Report Commissioned By :

Nature Biotechnology

Objectives of the Report The report aimed to develop a reliable method to turn human induced pluripotent stem cells (iPS cells) into functional hematopoietic stem cells (HSCs). These cells needed

Preclinical Evaluation of Transaxial Intramutaminal Trajectory for Enhanced Distribution of Grafted Cells in Parkinson’s Disease Summary

Author or authors of report : Marina E. Emborg, MD, PhD, and colleagues

Date of report : 2024-07-26

Medical conditions :

Parkinsons

Report Commissioned By :

Aspen Neuroscience, Inc.

Introduction This comprehensive study, conducted by Marina E. Emborg and colleagues, published on July 26, 2024, investigates a novel surgical technique for administering human-induced pluripotent stem cell-derived dopaminergic neuroprogenitor cells

Summary of the Report “MSCs Mediate Long-term Efficacy in a Crohn’s Disease Model by Sustained Anti-inflammatory Macrophage Programming via Efferocytosis

Author or authors of report : Maneesh Dave, Atul Dev, Rodrigo A. Somoza, et al.

Date of report : 2024-01-20

Medical conditions :

Crohn’s Disease

Report Commissioned By :

Research was conducted in partnership with the Australian Regenerative Medicine Institute.

Introduction and Background The study, led by Maneesh Dave and a diverse team of researchers, explores the therapeutic potential of human bone marrow-derived mesenchymal stem cells (hMSCs) in treating Crohn’s

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