Ataxia
Autism
Autoimmune Disorders
Cancer
Cerebral Palsy
Covid 19
Crohn’s Disease
Diabetes
Duchenne muscular dystrophy (DMD)
Lupus
Muscular Dystrophy
Optic Nerve Atrophy
Parkinsons
Spina Bifida
Spinal Cord Injury
Spinal muscular atrophy
Spinal Muscular Atrophy (SMA)

Allogeneic Mesenchymal Stem Cell Therapy with Laromestrocel in Alzheimer’s Disease: A Phase 2a Trial

Author or authors of report : Brian G. Rash, Kevin N. Ramdas, Anthony A. Oliva Jr.
Date of report : 2025-03-10
Alzheimer's Disease
Nature Medicine
Summary of the Main Points/Findings Background and Objective: This randomized, double-blind, placebo-controlled, parallel-group phase 2a clinical trial aimed to assess the safety and efficacy of laromestrocel, a bone-marrow-derived allogeneic mesenchymal
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Pre-clinical Safety and Efficacy of Human Induced Pluripotent Stem Cell-Derived Midbrain Dopaminergic Progenitor Cells for Parkinson’s Disease

Author or authors of report : Jeha Jeon, Young Cha, Yean Ju Hong, In-Hee Lee, Heejin Jang, Sanghyeok Ko, Serhiy Naumenko, Minseon Kim, Hannah L. Ryu, Zenith Shrestha, Nayeon Lee, Tae-Yoon Park, HoeWon Park, Seo-Hyun Kim
Date of report : 2025-03-06
Parkinsons
Cell Stem Cell
Summary of the Main Points/Findings: Background and Objective: This preclinical study aimed to assess the safety, quality, and functional potential of midbrain dopaminergic progenitor cells derived from patient-specific human induced
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Industry Updates from the Field of Stem Cell Research and Regenerative Medicine November 2024 (Summary)

Author or authors of report : Dusko Ilic and Mirjana Liovic
Date of report : 2025-01-19
Autoimmune Disorder, Cancer, Degenerative Disease
Regenerative Medicine Journal (Taylor & Francis Group)
Summary of the Main Points/Findings Background and Objective: This report offers a curated overview of major commercial and scientific developments within the field of stem cell research and regenerative medicine
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Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A

Author or authors of report : Alok Srivastava, M.D., Aby Abraham, D.M., Fouzia Aboobacker, D.M., Gurbind Singh, Ph.D., Tulasi Geevar, M.D., Uday Kulkarni, D.M., Sushil Selvarajan, D.M. , Trent Spencer, Ph.D.
Date of report : 2024-12-09
Hemophilia
New England Journal of Medicine
Summary of the Main Points/Findings Background and Objective: This single-center study aimed to evaluate the safety and efficacy of autologous CD34+ hematopoietic stem cells (HSCs) transduced with a lentiviral vector
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Allogeneic Umbilical Cord-Derived Mesenchymal Stromal Cells in Severe Systemic Lupus Erythematosus: A Phase 1 Trial

Author or authors of report : Prof Dominique Farge, MD, Lucie Biard, PhDd, Ben Weil, EngDe, Virginie Girault, PhD, Pauline Lansiaux, PhD, Ingrid Munia, MS, Séverine Loisel, PhD, Catney Charles, BSca, Judikael Saout, PhD
Date of report : 2024-12-17
Lupus (SLE)
Fondation du Rein, ANR eCellFrance
Summary of the Main Points/Findings Background and Objective: This phase 1, dose-escalation trial aimed to assess the safety and preliminary efficacy of allogeneic umbilical cord-derived mesenchymal stromal cells (UC-MSCs) in
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Induced Pluripotent Stem-Cell-Derived Corneal Epithelium for Transplant Surgery

Author or authors of report : Takeshi Soma, MDa, Yoshinori Oie, MDa, Hiroshi Takayanagi, MSa, Shoko Matsubara, BA, Tomomi Yamada, PhDd, Masaki Nomura, PhD
Date of report : 2024-11-16
Corneal Degeneration
The Lancet
Summary of the Main Points/Findings: Background and Objective: This single-arm, open-label, first-in-human interventional study in Japan aimed to assess the safety and feasibility of transplanting induced pluripotent stem-cell-derived corneal epithelium
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Creating Functional Hematopoietic Stem Cells from iPS Cells for Blood Disorders and Beyond (Report summary)

Author or authors of report : Elizabeth S. Ng, Gulcan Sarila, Jacky Y. Li, Hasindu S. Edirisinghe, Ritika Saxena, Shicheng Sun, Freya F. Bruveris, Tanya Labonne, Nerida Sleebs, Alexander Maytum, Raymond Y. Yow, Chantelle Inguanti, Ali Motazedian, Vincenzo Calvanese, Sandra Capellera-G
Date of report : 2024-09-02
Diabetes, Spinal Cord Injury
Nature Biotechnology
Objectives of the Report The report aimed to develop a reliable method to turn human induced pluripotent stem cells (iPS cells) into functional hematopoietic stem cells (HSCs). These cells needed
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Preclinical Evaluation of Transaxial Intramutaminal Trajectory for Enhanced Distribution of Grafted Cells in Parkinson’s Disease Summary

Author or authors of report : Marina E. Emborg, MD, PhD, and colleagues
Date of report : 2024-07-26
Parkinsons
Aspen Neuroscience, Inc.
Introduction This comprehensive study, conducted by Marina E. Emborg and colleagues, published on July 26, 2024, investigates a novel surgical technique for administering human-induced pluripotent stem cell-derived dopaminergic neuroprogenitor cells
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Summary of the Report “MSCs Mediate Long-term Efficacy in a Crohn’s Disease Model by Sustained Anti-inflammatory Macrophage Programming via Efferocytosis

Author or authors of report : Maneesh Dave, Atul Dev, Rodrigo A. Somoza, et al.
Date of report : 2024-01-20
Crohn’s Disease
Research was conducted in partnership with the Australian Regenerative Medicine Institute.
Introduction and Background The study, led by Maneesh Dave and a diverse team of researchers, explores the therapeutic potential of human bone marrow-derived mesenchymal stem cells (hMSCs) in treating Crohn’s
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Stem Cell Treatments Leading the Charge to Cure Cancer

Date of report : 2024-07-05
Cancer
Xianjing Chu, Wentao Tian, Jiaoyang Ning, Gang Xiao, Yunqi Zhou, Ziqi Wang, Zhuofan Zhai, Guilong Tanzhu, Jie Yang & Rongrong Zhou
Cancer stem cells (CSCs), a small subset of cells within tumors, possess self-renewal capabilities and play a crucial role in tumorigenesis, metastasis, and therapeutic resistance. These cells contribute significantly to
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