Summary
Diagnosis
Sex
Age
Nationality
Optic Nerve Hypoplasia (ONH) / Septooptic Dysplasia (SOD)
Female
10 years
Brazilian
Injections
Cell type
Admission date
Discharge date
8
2019-03-11
2019-03-28
Condition On Admission
The patient had light perception only. She had hormone deficiency (GH, thyroid, and cortisol) due to an atrophy in the pituitary gland.
Treatment Schedule
The patient received 8 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV), intrathecal and retrobulbar injections, as per the schedule below:
Number
Date
Cell Type
Delivery Method
Side Effects
1
2019-03-12
none reported
2
2019-03-15
Intrathecal Injection &
Intravenous Injection
none reported
3
2019-03-18
none reported
4
2019-03-22
none reported
5
2019-03-26
none reported
Condition at discharge
At discharge the patient already started to show some improvements; She could move her eyes following directions better than before. She could slowly move her eyes up and down and left and right. She could name the colors yellow, red, blue and purple by looking at colored lights (after she learned these colors). In addition, she could compare the size of shiny objects, finding out which ones were smaller or bigger and she could also identify their shapes.
Condition 12 months after treatment
At the 12 month follow up point, the patient’s parents reported that the patient’s quality of life had moderately improved and that improvements were continually being made. They also mentioned: “Before the treatment he only had light perception, today he is able to count on fingers.” Please see an excerpt from the patient’s parents 12 month assessment below:
Symptom
Parents’ Assessment of Improvement
Ability to focus eyes quickly
Small improvement
Ability to keep eyes focused for a long time
Moderate improvement
Ability to see hand movement
Moderate improvement
Ability to see things at a close distance
Moderate improvement
Ability to see things at a far distance
Significant improvement
Ability to see things clearly
Small improvement
Able to count fingers
Moderate improvement
Blindness
Moderate improvement
Colour vision
Significant improvement
Light perception
Moderate improvement
Night vision
Significant improvement
Nystagmus
Moderate improvement
Strabismus
Small improvement
Vision in left eye
Moderate improvement
Vision in right eye
Moderate improvement
Visual field
Small improvement
