Last Updated on: 4th September 2024, 05:12 pm
Summary
| Diagnosis | Sex | Age | Nationality |
|---|---|---|---|
| Optic Nerve Hypoplasia (ONH) / Septooptic Dysplasia (SOD) | Female | 16 months | Irish |
| Injections | Cell type | Admission date | Discharge date |
| 8 | UCMSC | January 16th 2011 | March 1st 2011 |
Condition On Admission
The patient had bilateral vision deterioration and a development delay since she was 5 months old. On physical examination her eyeballs were normal and pupils were equal and reactive to light. She could recognize light and darkness. Nystagmus was present. She could not look at objects and mostly let her head hang down to the floor when sitting.
Treatment Schedule
The patient received 8 umbilical cord-derived mesenchymal stem cell (UCMSC) packets by intravenous (IV) injections as per the schedule below:
| Number | Date | Cell Type | Delivery Method | Side Effects |
|---|---|---|---|---|
| 1 | 2011-01-19 | UCMSC | Intravenous Injection | none reported |
| 2 | 2011-01-21 | UCMSC | Intravenous Injection | none reported |
| 3 | 2011-01-24 | UCMSC | Intravenous Injection | none reported |
| 4 | 2011-01-28 | UCMSC | Intravenous Injection | none reported |
| 5 | 2011-02-11 | UCMSC | Intravenous Injection | none reported |
| 6 | 2011-02-16 | UCMSC | Intravenous Injection | none reported |
| 7 | 2011-02-21 | UCMSC | Intravenous Injection | none reported |
| 8 | 2011-02-25 | UCMSC | Intravenous Injection | none reported |
Condition at discharge
Stem cell treatment was completed without any adverse events or side effects. At the end of the treatment period the patient was able to reach out and grasp objects 50cm in front of her and track light with her eyes. There was also a decrease in the nystagmus.
Condition 1 month after treatment
One month after their daughter’s treatment the parents completed a Beike follow-up survey and in this survey they reported that their daughter had made significant progress in her physical condition and that her quality of life had significantly improved. At the time they also felt that new improvements were still being made by their daughter.
Condition 12 months after treatment
Please see an excerpt from the patient’s 12 month assessment below:
| Symptom | Parents’ Assessment of Improvement |
| Blindness | Significant improvement |
| Light perception | Significant improvement |
| Ability to see hand movement | Significant improvement |
| Vision in left eye | Significant improvement |
| Vision in right eye | Significant improvement |
| Night vision | Significant improvement |
| Ability to see things at a close distance | Significant improvement |
| Nystagmus | Significant improvement |
| Strabismus | Significant improvement |