Summary
| Diagnosis | Sex | Age | Nationality |
|---|---|---|---|
| Post-Anoxic Encephalopathy | Female | 23 years | French |
| Injections | Cell type | Admission date | Discharge date |
|---|---|---|---|
| 6 | UCBSC | 2019-07-13 | 2019-08-05 |
Medical history
In October 2009, the patient had ventricular fibrillation with cardiopulmonary arrest. MRI scan examination after the accident confirmed the diagnosis of post-anoxic encephalopathy. A defibrillator was installed as a safety precaution. Physiotherapy and speech therapy have had their effects for 9 years, but progress was minimal.
Condition On Admission
Before starting stem cell treatment the patient had secondary dystonia. She had walking difficulties and needed assistance. Most of the time she was moving around in a wheelchair. Eating was difficult because of high tension in the jaws. Food supplements were given to her at night thanks to a gastric tube. She had a hard time speaking as well because of tensions in the oral zone.
Treatment Schedule
Patient received 6 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV) injection and intrathecal way. In addition to the stem cell administrations, the patient also received a daily rehabilitation program that included physiotherapy, occupational therapy, aquatherapy, transcranial magnetic stimulation therapy, acupuncture and hyperbaric oxygen therapy.
| Number | Date | Cell Type | Delivery Method | Side Effects |
|---|---|---|---|---|
| 1 | 2019-07-16 | UCBSC | Intravenous Injection | None |
| 2 | 2019-07-19 | UCBSC | Intrathecal Injection | None |
| 3 | 2019-07-22 | UCBSC | Intrathecal Injection | None |
| 4 | 2019-07-16 | UCBSC | Intrathecal Injection | None |
| 5 | 2019-07-30 | UCBSC | Intrathecal Injection | None |
| 6 | 2019-08-02 | UCBSC | Intravenous Injection | None |
Condition 1 month after treatment
The patient’s parents mention a moderate improvement in quality of life and improvements are continually being made. They mention that the patient is less stiff, she can hold her head better and is more motivated for her physiotherapy and occupational therapy sessions. Please see an excerpt from the patient parent’s 1 month assessment below:
| Symptom | Parents’ Assessment of Improvement |
|---|---|
| Appetite | Small improvement |
| Balance | Moderate improvement |
| Breathing | Small improvement |
| Cooperation with others | Moderate improvement |
| Crawling | Moderate improvement |
| Drooling | Small improvement |
| Energy | Small improvement |
| Fine motor control | Moderate improvement |
| General mental ability | Small improvement |
| Hand control | Moderate improvement |
| Hyperactivity | Moderate improvement |
| Interaction with others | Moderate improvement |
| Limb muscle strength | Moderate improvement |
| Movement in general | Moderate improvement |
| Overall strength | Moderate improvement |
| Range of movement | Significant improvement |
| Reading | Small improvement |
| Seizures | Small improvement |
| Spasticity | Moderate improvement |
| Speech | Moderate improvement |
| Standing up | Significant improvement |
| Swallowing | Small improvement |
| Trunk control | Moderate improvement |
| Trunk muscle strength | Small improvement |
| Vision | Small improvement |
| Walking | Moderate improvement |
| Writing | Small improvement |
