Introduction:
- CP is a set of permanent movement and posture development disorders, often accompanied by other disturbances like sensation, perception, cognition, communication, behavior, epilepsy, and secondary musculoskeletal problems.
- The global prevalence rate is approximately 3 per 1000 births, with higher rates in some developing countries.
- Causes of CP include perinatal stroke, low birth weight, birth complications, gestational age, multiple births, and infections. Some patients may have genetic mutations linked to CP.
- Traditional treatments, including physiotherapy, occupational and speech therapy, assistive devices, pharmacological intervention, and surgeries, have limited efficacy for CP.
- Recent studies suggest stem cell therapy might effectively treat CP due to the multi-directional differentiation potential and migration capabilities of stem cells.
Clinical Trials:
- Children with CP have shown improvements in various functions after receiving stem cell infusion.
- However, the design of these clinical trials varies greatly, making it challenging to evaluate and compare outcomes.
- More research is required before stem cells can be used in clinical practice for CP.
- The article also provides a data retrieval of clinical trials related to stem cell therapy for CP, with details like project identifier, sample size, age, intervention model, status, phase, type of stem cell, infusion route, study dates, and location.